Search results for " SAR"
showing 10 items of 748 documents
SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders
2022
Abstract Background The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. Patients and methods A prospective multicenter registry-based cohort study conducted from December 2020 to December 2021 by the Spanish transplant and cell therapy group was used to analyze the relationship of antibody response at 3–6 weeks after full vaccination (2 doses) with breakthrough SARS-CoV-2 infection in 1394 patients with hematological disorders. Results At a median follow-up of 165 days after complete immunization, 37 out of 1394 (2.6%) developed breakthrough SARS-CoV-2 infection at median of 77 …
Diabetes and renin-angiotensin-aldosterone system: Implications for covid-19 patients with diabetes treatment management
2020
In the context of the COVID-19 continuous spreading, this paper focuses on the increased risk of diabetic patients regarding the metabolic control and the uncertainties related to SARS-CoV-2 infection. Chronic hyperglycaemia negatively affects the immune system, which triggers an increase of morbidity and mortality for viral infections. A key aspect of COVID-19 resides in the involvement of renin-angiotensin-aldosterone (RAAS) system that causes a cascade of reactions mediated by vasoactive peptides with implications in vasoconstriction, vascular permeability, oxidative stress remodelling and tissue injuries. Activation of RAAS at pulmonary level, is responsible for the local damage. Many q…
The Synergistic Impacts of Anthropogenic Stressors and COVID-19 on Aquaculture: A Current Global Perspective
2021
13 pages, 6 figures, 2 tables.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License
Scale dependence of species–area relationships is widespread but generally weak in Palaearctic grasslands
2021
Questions: Species–area relationships (SARs) are fundamental for understanding biodiversity patterns and are generally well described by a power law with a constant exponent z. However, z-values sometimes vary across spatial scales. We asked whether there is a general scale dependence of z-values at fine spatial grains and which potential drivers influence it. Location: Palaearctic biogeographic realm. Methods: We used 6,696 nested-plot series of vascular plants, bryophytes and lichens from the GrassPlot database with two or more grain sizes, ranging from 0.0001 m² to 1,024 m² and covering diverse open habitats. The plots were recorded with two widespread sampling approaches (rooted presenc…
Fine‐grain beta diversity of Palaearctic grassland vegetation
2021
QUESTIONS: Which environmental factors influence fine-grain beta diversity of vegetation and do they vary among taxonomic groups? LOCATION: Palaearctic biogeographic realm. METHODS: We extracted 4,654 nested-plot series with at least four different grain sizes between 0.0001 m² and 1,024 m² from the GrassPlot database, covering a wide range of different grassland and other open habitat types. We derived extensive environmental and structural information for these series. For each series and four taxonomic groups (vascular plants, bryophytes, lichens, all), we calculated the slope parameter (z-value) of the power law species–area relationship (SAR), as a beta diversity measure. We tested whe…
Planktonic stages of small pelagic fishes (Sardinella aurita and Engraulis encrasicolus) in the central Mediterranean Sea: The key role of physical f…
2018
Abstract Multidisciplinary studies are recently aiming to define diagnostic tools for fishery sustainability by coupling ichthyoplanktonic datasets, physical and bio-geochemical oceanographic measurements, and ocean modelling. The main goal of these efforts is to understand those processes that control the dispersion and fate of fish larvae and eggs, and thus tuning the inter-annual variability of the biomass of small pelagic fish species. In this paper we analyse the distribution of eggs and larvae as well as the biological features of the two species of pelagic fish, Engraulis encrasicolus and Sardinella aurita in the north-eastern sector of the Sicily Channel (Mediterranean Sea) from ich…
Small pelagic fish in the new millennium: A bottom-up view of global research effort
2021
The present review is an outcome of discussions at the ICES-PICES Symposium on Drivers of Dynamics of Small Pelagic Fish convened in Victoria, B.C., Canada in spring 2017.-- This review is a first contribution of a new international Working Group on Small Pelagic Fish started jointly by ICES (WGSPF) and PICES (WG43) to continue world-wide collaboration to advance knowledge on the drivers of populations of SPF.
Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases
2020
Abstract Background SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to SARS-CoV-2 play a crucial role in determining the clinical course after first infection. Immunological studies have focussed on patients with moderate to severe disease, demonstrating excessive inflammation in tissues and organ damage. We have studied the individual response to SARS-CoV-2 of asympromatic, mild and severe COVID-19 patients in order to investigate the role of innnate and adaptive immunity in determining the clinical course after first infection. Methods To understand the basis of th…
Mediterranean diet and sars-cov-2 infection: Is there any association? a proof-of-concept study
2021
The aim of this observational study was investigating the possible correlation between adherence to the Mediterranean diet (MeD) and SARS-COV-2 infection rates and severity among healthcare professionals (HCPs). An online self-administrated questionnaire (evaluating both MeD adherence and dietary habits) was filled out by HCPs working in Piedmont (Northern Italy) from 15 January to 28 February 2021. Out of the 1206 questionnaires collected, 900 were considered reliable and analyzed. Individuals who reported the SARS-COV-2 infection (n = 148) showed a significantly lower MeD score, with a lower adherence in fruit, vegetables, cereals, and olive oil consumption. In a logistic regression model…
Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
2017
Abstract Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumors with variable clinical, morphologic, and phenotypic characteristics. Transcriptome analysis was performed on multiple FDC sarcomas and compared with other mesenchymal tumors, microdissected Castleman FDCs, and normal fibroblasts. Using unsupervised analysis, FDC sarcomas clustered with microdissected FDCs, distinct from other mesenchymal tumors and fibroblasts. The specific endowment of FDC-related gene expression programs in FDC sarcomas emerged by applying a gene signature of differentially expressed genes (n = 1,289) between microdissected FDCs and fibroblasts. Supervised analysis comparing FDC sarcomas with mi…